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Cytogenetic lab

Cytogenetic lab.

  • Karyotyping of bone marrow cells
  • Karyotyping  of peripheral blood
  • Assessment of chromosome
    breakage in patients with Fanconi anemia using MMC
  • Assessment of chimerism in patients who underwent  sex -mismatched bone marrow transplant using FISH
  • Assessment of prognostic panel on peripheral blood of CLL patients using FISH analysis and assessment of the following genes:

                                           IGH (14q32) break, ATM (11q22)/SE11,

                                           DLEU (13q14)/p53 (17p13),

                                            GLI (12q13)/se12, 6q21/MYC (8q24)

  • Assessment of prognostic panel on bone marrow plasma cells of patients with Multiple myeloma using FISH and assessment of the following genes:

                           1q21/8p21, 15q22/6q21, 11q23/DLEU (13q14), 15q22/9q34

                            IGH Break, FGFR3/IGH t (4; 14), 19q13/p53 (17p13)

                           MAF/IGH t (14; 16), 1q21 / SRD (1p36), t (11; 14)

  • Assessment of  PML/PARA and RARA Break fusion (reciprocal and non-reciprocal) in patients with AML M3 using FISH
  • Assessment of  BCR/ABL fusion (reciprocal and non-reciprocal) in patients with CML using FISH
  • Assessment of  Burkitt Lymphoma translocation : MYC/IGH t(8,14)fusion, other MYC translocation, BCL2/IGH t(14,18)
  • Assessment of  prognostic genes in patients with AML and ALL using FISH
  1. MLL Break (11 q23), CBFB t (16,16); in v(16) EVI
  2. T (3;3), inv (3)(3q26) break, ETV6 (TEL) (12p13)
  3. P16 (9 q 21)/ P53 (17 P13)/ MPO (17q22) ISO 17 q
  • Assessment of  BCL-2 gene translocations in patients with Follicular lymphoma using FISH
  •  Assessment of CCND1 (BCL1; 11q13) gene translocations in patients with Mantle Cell Lymphoma
  • Assessment of 5q in patients with MDS and AML using hTERT (5q15)/5q31 probe
  • Assessment of  PDGFRA translocation in patients with PDGFRB, CMPD, CEL,HES and CML (typical and atypical)
  • Assessment of  BCL6 translocation in patients with Bcell NHL
  • Assessment of JAK2 translocation in Myeloproliferative Neoplasm